Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

• The usual starting dose is 50mg, taken approximately one hour before sexual activity.
• Dosage can be adjusted depending on individual response and tolerability.
• Take only one tablet in 24 hours, with or without food.
• Avoid grapefruit juice, as it can increase the risk of side effects.
• A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

• Headache
• Flushing
• Nasal congestion
• Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

• Taking nitrates for chest pain
• With severe heart or liver conditions
• Under 18 years of age
• With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

• Nitrates
• Alpha-blockers
• Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

• Generic versions are more affordable than branded Viagra.
• Supplied by licensed UK pharmacies such as Online Chemist.
• Avoid counterfeit products from unregulated websites.

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Side Effects of Sildenafil

Common:nosebleed, dizziness, feeling anxious, streamlined, hostile system, difficulty in getting an erection, priapism

Less common:impotence, erectile dysfunction, urinary tract infection, sexual dysfunction, muscle ache, painful erection, painful ejaculation, painful sexual intercourse

Pregnancy and Breastfeeding

Sildenafil is pregnancy and breastfeeding safe.

Drug Interactions with Other Medications

A high-fat meal may reduce the effectiveness of Sildenafil, cause changes to its absorption rate, or it may affect how your body absorbs Sildenafil. Do not take more than one tablet within a 24-hour period.

Salt Composition in both

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Disclaimer

PlatinumRx is dedicated to delivering dependable and trustworthy information to empower our customers. However, the information presented here is solely for general informational purposes and should not be utilized for diagnosing, preventing, or treating health issues. It is not intended to establish a doctor-patient relationship or serve as a substitute for professional medical advice.

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Sildenafil is used to treat erectile dysfunction or enlarged prostate. It increases blood flow to the penis. This helps to improve the ability to achieve and maintain an erection.

Sildenafil (Phosphodiesterase Type-5 Inhibitor)

Sildenafil is an anti-hypertensive drug. It reduces blood pressure by relaxing blood vessels. It also increases the blood flow to the penis during sexual stimulation.

Benefits

• Used for for use during arousal.
• It is usually recommended to take it about 30 minutes to an hour before sexual activity.
• Can be taken by adults and in some cases, males and children between the ages of 8 and 18.
• Potential side effects include headache, nausea, facial flushing, indigestion, and stomach discomfort.
• Sildenafil is not intended for use by women and children.

How To Use

The recommended starting dose of sildenafil for treating erectile dysfunction and enlarged prostate is 50 mg. The dose may vary depending on the severity of your condition and individual response. Your doctor may then adjust your dosage accordingly.

It is important to follow the dosage instructions provided by your doctor. Take sildenafil at the same time every day, with or without food, as instructed by your doctor. Avoid taking it for long if you have heart conditions, high blood pressure, or eye or liver disease.

Precautions

You should handle sildenafil safely and in the correct dosage. Avoid taking it with nitrates, as this may lead to a dangerous drop in blood pressure. Individuals with liver or kidney disease should exercise caution as sildenafil may be more likely to cause side effects. The medication may not be suitable for individuals with certain medical conditions or those taking certain medications. Before you take sildenafil, prime the measuring cup with measuring strips of 8 or 8+ in a counter.

Read the medicine label carefully and follow the directions for use if advised by your doctor. Do not use the oral tablet or the injectable forms of the medication without doctor’s advice.

Sildenafil Side Effects

Some common side effects of sildenafil include:

• Headache
• Flushing (warmth, redness, or tingly feeling)
• Indigestion
• Back pain
• Muscle pain
• Nausea
• Diarrhea
• Flushing is more likely to occur after the administration of a cold or flu medicine or during the administration of a combination medicine called “cold sildenafil”.

Warnings, Precautions & Warnings

• Keep out of reach of children.
• Store at room temperature between 15-30 degrees C (59-86 degrees F).
• Keep this medicine out of the reach of children and in its original container. It should not be stored by the store.
• Do not use sildenafil if you have an allergy to any of the ingredients in this medicine or to any of the other ingredients in the medicine. Injectable medications can include sildenafil.
• Before using this medicine, inform your doctor if you have liver disease, diabetes, heart disease, hyperthyroidism, or other heart problems. In case you experience any of these symptoms, contact your doctor about an alternative treatment.
• Do not use sildenafil if you are taking any of the following medications: angiotensin-converting enzyme (ACE) inhibitors, angiotensin-II receptor blockers, brominated/monoformersulphine, cyclosporine, digoxin, heparin, lithium, oral contraceptives, other medications for erectile dysfunction (OCE), hypertension, high blood pressure, and/or heart failure.
• Amlodipine
• Carbamazepine
• Clopidogrel
• Furosemide
• Lithium
• Methadone
• Riociguat
• St. John’s wort

Note: All other medications require consulting a doctor before use.

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Salladha, R. E. & Bajaj, D. The mechanism of action of sildenafil. J Med Chem. 2002, 42, 2153-2175.

Pfister, R. The molecular mechanism of sildenafil citrate and sildenafil citrate analogues: new perspectives for sildenafil citrate. J Pharm Biomed. 2008, 17, 10-29.

Sildenafil citrate: molecular mechanism and pharmacological properties. 2008, 17, 3-15.

Sildenafil citrate: pharmacological properties of sildenafil and its chemical composition. Pharm Biomed Pharmacol. 2008, 18, 6-9.

Sildenafil citrate: pharmacological properties of sildenafil citrate and its chemical composition. 2008, 18, 5-9.

Bajaj, D. The molecular mechanism of sildenafil citrate. 2008, 17, 6-10.

2008, 17, 4

The molecular mechanism of sildenafil citrate: new perspectives for sildenafil citrate. 2008, 17, 5-9.

Sildenafil citrate: pharmacological properties of sildenafil citrate.

Kobayashi, M. H. & Shukan, M. Sildenafil citrate and sildenafil citrate analogues in treatment of erectile dysfunction. 2007, 17, 15-21.

The molecular mechanism of sildenafil citrate and sildenafil citrate analogues. 2008, 18, 10-22.